Hepatitis E – What role do animal products play in the transmission?
Virus findings in pork, liver sausage and more
Sep 2020. Recent studies conducted by the University Hospital Tübingen in cooperation with the Robert Koch Institute (RKI), the Federal Institute for Risk Assessment (BfR) and the Hannover Medical School (MHH) have shown that more than ten percent of pork and pig liver in Germany is contaminated with hepatitis E viruses. The researchers had examined around 130 food samples from butchers' shops and supermarkets. Pork liver, liver sausages and pâtés as well as raw sausages were tested 1.
Analytical detection of hepatitis E viruses to support your risk management
In this context, Eurofins developed – already one year before the publication of the §64 LFGB standard - its own method for the detection of HEV with special sample preparation and subsequent multiplex RT-PCR. With the validated test, even a very small amount of sample material is sufficient to reliably detect very low concentrations of the virus. Fields of application of this analysis are hygiene controls in slaughterhouses and meat-cutting plants as well as controls of HEV-risk foods such as pork, game meat and products containing liver (e.g. liver sausage or liver pâté).
It should be noted that virus detection as such does not allow a statement about infectivity, as the heat effect during the production of the products can lead to inactivation of the viruses. At European level, EFSA identifies raw pork and liver as the main causes of hepatitis E infection in the EU 2. Accordingly, consumers should make sure that meat and offal are well cooked (at least 71°C for 20 minutes). In addition, hygienic, professional cutting and processing of carcasses is necessary to minimise the risk for producers.
Properties and occurrence of the hepatitis E virus
The hepatitis E virus (HEV) is an unenveloped RNA virus that can cause liver inflammation in humans, which can be particularly dangerous for immunocompromised persons, the elderly, children and pregnant women (YOPI). HEV occurs in four genotypes, with genotypes 1 and 2 exclusively affecting humans and being endemic in Africa and Asia. Hepatitis E is therefore mainly known as a travel disease, which is transmitted faecal-orally via drinking water when hygiene standards are inadequate. However, since the introduction of compulsory reporting in 2001, the number of registered diseases acquired in Germany (so-called autochthonous infections) has risen sharply. These cases are infections with subtypes 3 and 4, which also have reservoirs in pigs, wild boars and other mammals and are zoonotic. Meanwhile, the prevalence in animal populations has risen steeply. According to the German Federal Institute for Risk Assessment (BfR), the prevalence in German domestic pig populations is 40 to 50 %, in wild boar it is 2 to 68% 3. Pigs show no clinical symptoms of HEV infection.
Emerging pathogens – Keeping an eye on new microbiological hazards
Globalised commodity flows, international travel and changing climatic conditions allow microorganisms to colonise new niches. In the case of pathogenic germs, these so-called "emerging pathogens" can pose a danger to the population and should therefore be continuously monitored. An evaluation of the current epidemiological situation in Germany shows that especially food-associated infections of viral origin are on the rise.
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Quellenangaben
1 In German: Hepatitis-E-Viren in Schweinefleisch nachgewiesen (Hepatitis E virus detected in pork). Press release by the University Hospital Tübingen of 8 September 2020
2 Hepatitis E: raw pork is main cause of infection in EU. Press release by the EFSA of 11 Juli 2017
3 Questions and answers on the transmission of the hepatitis E virus through wild boars and domestic pigs and foods derived from them. FAQ from the German Federal Institute for Risk Assessment (BfR) of 9 Februar 2016