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Analysis of neonicotinoids

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Upcoming amendments to thiacloprid and acetamiprid

Aug 2024. The EU Commission is planning to abolish the current import tolerances for thiacloprid and reduce the maximum residue levels for the corresponding products. In addition, the European Food Safety Authority (EFSA) recommends reducing the Acceptable Daily Intake (ADI), the Acute Reference Dose (ARfD) and the Maximum Residue Levels (MRLs) for acetamiprid.

We give you a compact overview of the upcoming amendments to thiacloprid and acetamiprid, as well as the active substance group of neonicotinoids.

Proposed repeal of the current EU import tolerances for thiacloprid

On 8 May 2024, the European Commission notified the World Trade Organization (WTO) that the import tolerances for thiacloprid will be repealed and the maximum residue levels for all products will be reduced to the product-specific technical detection limits[1]. The current draft of the regulation to reduce the maximum levels for thiacloprid PLAN/2023/961_Rev8[2,3,4] is expected to be published in the Official Journal of the European Union on 11 December 2024 and will enter into force 6 months after publication. No transition period is planned.

The approval of thiacloprid has already been revoked on 3 August 2020. The use-by date for formulations containing thiacloprid ended on 3 February 2021, since then the use of thiacloprid as an insecticide is no longer authorised in the EU. However, there are still import tolerances for thiacloprid for numerous products, some of which are well above the product-specific technical detection limits.

The European Commission's proposal to extend the import tolerances for thiacloprid (COM(2023)0739 - 2023/3005(RPS)[5] was rejected by the European Parliament's Environment Committee with reference to the potentially harmful effects of thiacloprid on human health and its toxic effects on aquatic organisms and pollinating insects[6].

In February 2024, France adopted a national law prohibiting the marketing of fruit and vegetables containing thiacloprid residues above 0.01 mg/kg. This national regulation will be repealed as soon as the new EU regulation is adopted, or after one year at the latest.

EFSA recommends lowering the ADI and ARfD for Acetamiprid

In its latest statement on the toxicological properties and MRLs of acetamiprid, published on 27 March 2024, EFSA recommends lowering the ADI and ARfD from 0.025 to 0.005 mg/kg body weight (per day). Furthermore, EFSA proposes a reduction of the acetamiprid MRLs for 38 different products, as the new, lower ARfD for these products may be exhausted by more than 100% even if the existing acetamiprid MRL is not exceeded.

The new EFSA recommendations are based on new scientific findings that indicate that acetamiprid has adverse effects on the development of the human brain and nervous system. However, there are still uncertainties in the evidence regarding the developmental neurotoxicological properties of acetamiprid, which is why further data are needed to allow a proper hazard and risk assessment[7].

Current regulatory situation of neonicotinoids in the EU

The most economically important neonicotinoid active substances worldwide are imidacloprid, thiamethoxam, clothianidin, acetamiprid, thiacloprid, dinotefuran and nitenpyram. Of these, only acetamiprid is still approved as an insecticide in the EU. With the exception of nitenpyram, for which the default MRL of 0.01 mg/kg applies, import tolerances exist for various products.

With the exception of dinotefuran, the existing tolerances will be gradually reduced to the product-specific technical detection limits in the coming years.

Application and mode of action of neonicotinoids

Neonicotinoids are systemic insecticides. They are absorbed by plants via the roots and leaves and distributed systemically throughout the plant. As a result, the active ingredients in this group are particularly effective against biting and sucking insects. Due to their systemic properties, neonicotinoids are mainly used for the treatment of seed, but also as sprays and as additives to irrigation water.

Neonicotinoids are only decomposed slowly in plants, meaning that they remain effective for a long time and can be ingested directly by humans[8].

(Eco)toxicology of neonicotinoids

In addition to their toxic effects on biting and sucking insects, it has been shown in recent years that neonicotinoids also affect pollinating insects and, due to their high water solubility, aquatic organisms. For example, the EFSA confirms that the active substances are involved in increased bee mortality[9,10].

Neonicotinoids are considered to be moderately toxic to mammals. However, some neonicotinoid active substances may have a high potential for bioaccumulation as well as reproductive toxicity and neurotoxic effects in mammals[11].

We support you in the analysis of neonicotinoids

Neonicotinoids such as imidacloprid, acetamiprid and thiacloprid are determined by LC-MS/MS as standard. The Eurofins Food & Feed Testing laboratories in Germany offer you the analysis of neonicotinoids in almost every LC-MS/MS pesticide screening or in every screening package that includes a liquid chromatographic test. We support you in the analysis of neonicotinoids in a wide range of products.

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Do you have questions about the analysis of neonicotinoids? Contact your personal account manager or get in touch with our experts directly.

Relevante Quellen

[1] WTO (2024). Committee on Sanitary and Phytosanitary Measures (Notification)
[2] PLAN/2023/961_Rev8; Amending Annexes II and V to Regulation (EC) No 396/2005 of the European Parliament and of the Council as regards maximum residue levels for thiacloprid in or on certain products 
[3] PLAN/2023/961_Rev8; Annex
[4] PLAN/2023/961_Rev8; Annex V 
[5] European Comission (2023). Proposal for a Council Regulation amending Annex II to Regulation (EC) No 396/2005 of the European Parliament and of the Council as regards maximum residue levels for thiacloprid in or on certain products
[6] European Parliament (2023). Draft motion for a resolution on the proposal for a Council regulation amending Annex II to Regulation (EC) No 396/2005 of the European Parliament and of the Council as regards maximum residue levels for thiacloprid in or on certain products (COM(2023)0739 – 2023/3005(RPS))
[7] EFSA (2024). Statement on the toxicological properties and maximumresidue levels of acetamiprid and its metabolites
[8] Bundesinformationszentrum Landwirtschaft (2024). Neonicotinoide - ein Risiko für Bienen (in German)
[9] EFSA (2018). Neonicotinoide: Risiken für Bienen bestätigt (in German)
[10] LANUV NRW (2015). ECHO-Stoffbericht Neonicotinoide (in German)
[11] EFSA (2013). EFSA assesses potential link between two neonicotinoids and developmental neurotoxicity